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Keywords = bioactivity

  • Open Access Research Article
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    Trends Journal of Sciences Research 2014, 1(1), 38-48. http://doi.org/10.31586/Biochemistry.0101.06
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    Abstract
    The biological activity of chemical compounds is analyzed using electronic and information factors. We found a linear interrelation between the electronic and information factors of molecules. Moreover, these molecular factors are calculated from different principles. Electronic factor is determined by the quantum-mechanical method from the molecular pseudopotential, whereas the information
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    The biological activity of chemical compounds is analyzed using electronic and information factors. We found a linear interrelation between the electronic and information factors of molecules. Moreover, these molecular factors are calculated from different principles. Electronic factor is determined by the quantum-mechanical method from the molecular pseudopotential, whereas the information factor is determined by using the information function. It is shown that these factors are separated off statistically significant bioactive chemical compounds of inactive chemicals. To determine these factors is sufficient to know only the chemical formula of molecules. We analyzed the chemical compounds for toxicity, antiradiation activity, carcinogenicity, antifungal activities. To identify biologically active chemical compounds we used the statistical conjugation method of qualitative attributes.  Full article
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    References
    [1]
    Bacq Z.M., Alexander P. (1961). Fundamentals of Radiobiology. Pergamon Press, Oxford ? New-York ? Paris.
    [2]
    Veljkovi? V., Lalovi? D. (1973). General model pseudopotential for positive ions. Phys. Lett., 45A, 59-60.
    [3]
    Mukhomrov V.K. (2014). Biological Activity of Chemical Compounds and their Molecular Structure ? Information Approach. J. Chem. Eng. Chem. Res., 1(1), 54-65.
    [4]
    Veljkovi? V., Lalovi? D. (1977). Experienta, 33(9), 1228.
    [5]
    Sweeney T.R. (1979). Survey of compounds from the antiradiation drug development programm. Washington.
    [6]
    Romantzev, E.F. (1968). Radiation and chemical protection. Nauka, Moscow, 1968 (in Russian).
    [7]
    F?rster E., R?nz B. (1979). Methoden der Korrelations- und Regressionsanalyse. Verlag Die Wirtschaft. Berlin.
    [8]
    Shannon C. (1948). A Mathematical Theory of Communications. Bell Syst. Techn. Journal. 27, 379-423.
    [9]
    Kolmogorov A.N. (1987). Information Theory and Theory of Algotithms. Nauka. Moscow. (in Russian).
    [10]
    Pustyl?nik E.I. (1968). Statistical Methods of Analysis and Processing Observations. Nauka, Moscow. (in Russian).
    [11]
    Westland R.D. (1968). N-Substituted S-2 Aminoethyl Thiosulfates as Antiradiation agents. J. Med. Chem. 11, 1190-1201.
    [12]
    Mukhomorov V.K. (2013). Linking the Radio-Protective Effects of Tryptamine Analogues with their Electronic and Steric Properties via Quantum Mechanics Calculations. Chem. Rapid Commun. 1(1), 15-20.
    [13]
    Turusov, V.S. (1964). Cancerogenic Substances. Handbook. Nauka, Moscow, (in Russian).
    [14]
    Belenkaya I.A., Dyachina Zh.S., Mukhomorov V.K. (1991). Structure-Activity. Association of the Electronic Parameters of Substituted Benzo-2,1,3-Thia- and Selenadiazoles with their Antifungal Activity and Toxicity. Pharm. Chem. Journal.. 25(12), 900-906.
    [15]
    Golyshin N.M. (1970). Fungitsidy v sel'skom khozyaystve (Fungicides in Agriculture). M. (in Russian).
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